The University of Houston seeks to remain unbeaten on the road this season against No. 24 Arizona State at Mountain America Stadium.

Victory is the only goal for No. 24 Arizona State (5-2, 3-1) this week, as the Sun Devils welcome Houston (6-1, 3-1) to Tempe.

The Big 12 has changed dramatically over the past few years, with eight new teams joining to help keep the conference going strong after the departure of Texas

Arizona State star receiver Jordyn Tyson was ruled out for Saturday's game against Houston due to an apparent hamstring injury. Sam Leavitt is probable.

Here is the player availability report for the upcoming Arizona State football vs. Houston game on Oct. 25, 2025, at Mountain America Stadium.

This weekend, the Cougars head back out on the road and take a trip out west, taking on the Arizona State Sun Devils in Tempe. The matchup is the first time Houston takes a trip out to the desert in nearly 40 years, with the last time coming in 1989, which saw the Coogs victorious.

Seven UH players have been ruled out: wide receiver Stephon Johnson, who underwent season-ending surgery for a foot injury Wednesday, wide receiver Devan Williams, running back Stacy Sneed, wide receiver JayShon Ridgle, defensive lineman Quindario Lee, tight end Luke McGary and defensive back Kenzy West.

Pick OU: Over (45.5) Against the spread, Arizona State is 3-3-1 this season. As a 7-point or greater favorite, Arizona State has one win ATS (1-1) this season. Two of seven Arizona State games have hit the over this year. Houston is 5-2-0 against the spread this year.

While the Houston Cougars have sustained injuries in past weeks, the Arizona State Sun Devils could have some depth concerns this weekend.