Kickoff from Santiago Bernabeu Stadium in Madrid is set for 3 p.m. ET. The hosts are -500 favorites (risk $500 to win $100) on the 90-minute money line in the latest Real Madrid vs. Osasuna odds, while Osasuna are +950 underdogs.

Real Madrid got their 2025-26 La Liga campaign off to a winning start, beating Osasuna 1-0 at the Santiago Bernabeu. Kylian Mbappe scored from the spot early in the second half to give Xabi Alonso's side all three points.

Real Madrid is back in action for the 2025-26 La Liga season, with their first match kicking off this week. Date: Friday, August 15, 2025 – Sunday, May 24, 2026 ESPN+ offers a wide array of matches throughout the season, including every La Liga match during the 2025-26 season.

The 2025-26 La Liga season is here, as Real Madrid and Atletico Madrid are fighting to retake the division crown from Barcelona.