RB Christian McCaffrey is expected to play vs. the Titans despite a questionable tag, with multiple NFL insiders signaling good news.

Our experts' predictions are in for Tennessee Titans vs. San Francisco 49ers on Sunday. Here's who our experts are picking to win the Week 15 NFL game.

The San Francisco 49ers‘ defense has been ravaged by injuries, most notably to Fred Warner and Nick Bosa. Nonetheless, defensive coordinator Robert Saleh is working with what he has available and putting out a respectable group that has the Niners in a playoff spot heading into Week 15.

Sunday’s game at Levi’s Stadium could get out of hand quickly. The San Francisco 49ers will host the Tennessee Titans as 12.5-point favorites in Week 15. The un

See where the San Francisco 49ers stand in Week 15 power rankings as the team comes off its bye week, riding a three-game win streak.

Do the San Francisco 49ers play today? Find out their Week 14 NFL schedule here.

So if the Niners let him play out his contract, shake his hand, and watch him sign a solid $20-to-$30 (maybe $40) million-dollar deal elsewhere in free agency come the end of the 2026 season, the league office will essentially FedEx a third-round pick (fourth at worst) to Santa Clara. That’s money in the bank. That’s a free lottery ticket.

The San Francisco 49ers are doing so well in 2025 that they probably won't make a pick until later in the first round in the 2026 NFL draft.