The Arizona Cardinals (3–6) return home to take on the San Francisco 49ers (6–4) in what is pretty much a must-win game for them. Starting the season 0–3 in the

Brock Purdy threw a touchdown to George Kittle early in his second start as a pro in Arizona to move up the 49ers' record books as a duo.

San Francisco 49ers QB Brock Purdy dispensed with questions over his health and simultaneously silenced debate over Mac Jones' "hot hand" by piling up points to rout Arizona.

After a frustrating six-week wait to return from injury, 49ers quarterback Brock Purdy didn't take long to get back into a rhythm Sunday, throwing for 200 yards with three touchdowns and no interceptions in a blowout win over the Cardinals.

The Arizona Cardinals take on the San Francisco 49ers on Sunday at State Farm Stadium, kicking off at 4:05 p.m. ET (2:05 p.m. ET). The Cardinals are 3.5-point underdogs in this game. They are 1-6 in their last seven games and lost to the 49ers once already this season.

Darnold, who joined Seattle in the offseason, also helped Smith-Njigba join an elite club. He became only the third player after NFL legends Antonio Brown and Michael Irvin to record at least 75 receiving yards in each of their first nine games, according to the Associated Press. It was a good night for the Seahawks, safe to say.

The Arizona Cardinals are expecting breakouts from more than one member of their 2025 roster. With a defense — particularly the front seven — primed to take a massive jump in both overall talent and execution, a few names may stand out as more likely ...

In the absence of Kyler Murray, Jacoby Brissett's arm has led both Harrison and tight end Trey McBride to see bigger workloads in the Cardinals' passing game; Harrison posted a career-high seven receptions in a Week 9 win over the Dallas Cowboys.

The Seahawks are 6-2-0. They are tied for the lead in the NFC West Division with the Los Angeles Rams. Both of these teams have stingy defenses. They also have good offensive lines and elite receivers, as well as qualified quarterbacks.

Kyler Murray’s future with the Arizona Cardinals is under severe threat. With Arizona currently 3-6 entering Week 11 and with under fire head coach Jonathan Gannon preferring veteran

Arizona didn't prevail in Week 11, but their veteran quarterback still managed to turn in a historic outing against San Francisco.