The prostate highly depends on androgens for its growth, development and functioning. Castration therapies aim at blocking signaling through the androgen receptor (AR), cause atrophy and epithelium ...

The normal prostate epithelial structure is maintained by homeostatic interactions with smooth muscle cells. However, structural alterations of the stroma are commonly observed in prostatic ...

Texas lawmakers made voluntary castration available for sex offenders in 1997, and since then, three have been surgically castrated. While orchiectomy, surgical removal of the testes, may lower male ...

FOURTEEN years have passed since Huggins and Hodges 1 demonstrated the efficacy of castration and estrogen therapy in the treatment of carcinoma of the prostate. The frequently observed response of ...

Clinical and molecular features of ATM and BRCA2 mutations in metastatic prostate cancer. This is an ASCO Meeting Abstract from the 2023 ASCO Genitourinary Cancers Symposium. This abstract does not ...