Hurricane Melissa made landfall in Cuba overnight after battering Jamaica as one of the most powerful landfalling storms in Atlantic basin history.

The United States is prepared to offer immediate humanitarian aid to people of Cuba who were affected by Hurricane Melissa, U.S. Secretary of State Marco Rubio said on Thursday. The department has issued a declaration for humanitarian assistance for Cuba,

Secretary of State Marco Rubio said the State Department had issued a formal Declaration of Humanitarian Assistance for Cuba, where U.S. government aid is rare.

Hurricane Melissa is slamming eastern Cuba on Wednesday morning, Oct. 29, after hammering Jamaica on Tuesday and causing widespread damage.

The United Nations General Assembly overwhelmingly called for an end to a U.S. economic embargo on Cuba despite lobbying by Washington that included sharing an accusation that up to 5,000 Cubans are fighting alongside Russian forces in Ukraine.

After Melissa moves away from Jamaica, Cuba is next in line for the powerful hurricane’s fury. Landfall is expected very early Wednesday morning, likely a couple hours after midnight, but impacts have already begun.

The U.N. General Assembly has voted overwhelmingly to condemn the U.S. economic embargo of Cuba for a 33rd year.

The strongest storm to directly hit Jamaica before Melissa was Hurricane Gilbert in 1988, which made landfall as a category four hurricane, according to the US National Weather Service. Damaging winds and heavy rain have hit eastern Cuba, according to the latest update from the National Hurricane Center.