Diseases of later life represent a formidable human challenge 1. Existing hallmarks of ageing point to disparate but interconnected classes of causal factors leaving the search for unifying factors in ...

The human genome is broadly classified into the genome residing in the cell nucleus (nuclear DNA) and the genome residing in the mitochondria (mitochondrial DNA: mtDNA). Mitochondria are cell ...

C-to-T transitions in CpG dinucleotides are the most prevalent mutations in human cancers and genetic diseases. These mutations have been attributed to deamination of 5-methylcytosine (5mC), an ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Alphabet Inc.’s Google DeepMind today introduced AlphaGenome, a new artificial intelligence tool that can comprehensively predict how mutations or variants in human DNA sequences impact gene ...

Mitochondria are well known as the powerhouses of the cell because of their energy generating capabilities. These little organelles are very special, because they also carry their own tiny little ...

Only around two percent of the human genome codes for proteins, and while those proteins carry out many important functions of the cell, the rest of the genome cannot be ignored. However, for decades ...

In 2020, Jennifer Doudna won the Nobel Prize in chemistry for her work on the CRISPR-Cas9 gene-editing technology that allows ...

A reanalysis of whole-genome data from 130 children conceived after the Chernobyl disaster has identified a statistically significant increase in a specific type of DNA mutation in the offspring of ...