The study of DNMT3A structure with substrates has long been hindered by the difficulty in producing a stable enzyme-substrate complex.

The structure of a large nucleic acid complex formed by the 10–23 DNA enzyme bound to an RNA substrate was determined by X–ray diffraction at 3.0 Å resolution. The 82–nucleotide complex ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists have investigated a multi-enzyme complex that plays an essential role in ...

In addition, our analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of ...