Tetrapod limb development proceeds through several key stages (Fig. 1B–D; 4,5,6). In the ridge stage, limbs initiate at precise locations along the anterior–posterior axis extending from the flank, ...

A team of bioengineers at Instituto Gulbenkian de Ciência, in Portugal, has found that inactivating the Tgfbr1 gene in mouse embryos results in altered development in the trunk to tail region. Prior ...

Robinow Syndrome is the best known of a set of genetic disorders that affect the growth and development of the skeletal system. Patients with these conditions have facial abnormalities, such as cleft ...

To investigate the molecular origins of wing formation, we performed single-cell RNA sequencing (scRNA-seq) at multiple time points during bat and equivalent mouse embryonic limb development. Our data ...

Three-dimensional image of a developing limb bud generated using LimbLab. It shows where key genes are active during early limb formation. Sox9 (magenta) marks the cells that will become cartilage and ...

Studying the shape of tissues and organs is critical to understanding how they are formed. Embryonic development happens in three dimensions, but many studies are limited by the use of two-dimensional ...

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts - the most commonly found cells in skin and ...