The misfolded proteins responsible for a fatal neurological illness in deer have a twist. The first detailed structure of an infectious prion that causes chronic wasting disease, or CWD, reveals ...

We may have been overestimating the role of a pathological class of misfolded protein in neurodegenerative disease. Called prions, these molecules are responsible for conditions such as bovine ...

Using cryo-electron microscopy, researchers at Case Western Reserve University School of Medicine and National Institutes of Health open door to new level of detail in study of abnormal proteins that ...

Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both because it is difficult to treat and because of its high mortality rate. In ...

In the field of COVID-19 research, attention has turned to a critical aspect: the prion region on the surface spike proteins of the virus and its implications, especially in the context of mRNA ...

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death. Although the causal link between protein aggregates and ...

Alzheimer's disease and other neurodegenerative conditions can sometimes feature damaging clumps of tau proteins that have become deformed. Scientists have now synthesized these misshapen entities in ...

When proteins are made in a cell, they start out as strings of amino acids, which have to be folded into the correct, three-dimensional shape so they will function properly. Misfolded proteins can ...