Federal officials plan to send warning letters to companies marketing products with 7-OH, part of effort to fight America's ...

Activating mu-opioid receptors with positive allosteric modulators reduces pain.

Positive allosteric modulators (PAMs) of the mu-opioid receptor (MOR) have been hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on the idea that PAMs will ...

They found increased activity only in a brain area called the central amygdala. Selectively knocking out mu opioid receptors there eliminated withdrawal behaviors.

It acts on your mu opioid receptors. However, it doesn’t stimulate them as much as full opioid agonists, such as heroin or morphine. At the same time, it also works to block kappa opioid receptors.

Most current pain medications target the mu receptor, but UF researchers are pioneering a new strategy focused on the delta opioid receptor, which could offer pain relief with fewer side effects.