A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists have investigated a multi-enzyme complex that plays an essential role in ...

The study of DNMT3A structure with substrates has long been hindered by the difficulty in producing a stable enzyme-substrate complex.

The crystal structure of human stearoyl-CoA desaturase-1 in complex with its natural substrate provides a close-up view of a key enzymatic step in the synthesis of unsaturated fatty acids.

Enzyme-catalysed reactions require the specific interaction between the enzyme and its substrate in the Michaelis complex. Due to turnover, Michaelis complexes are typically transient making them ...

Research on γ-secretase reveals its unique substrate recognition mechanism, offering potential for developing precise therapeutic agents for various diseases.

This ion swap led to enzyme inactivation while retaining high-affinity substrate interactions. Cocrystallization of La3+-bound enzymes with Man₉GlcNAc₂ substrate analogs revealed enzyme–substrate ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research. The γ-secretase enzyme is capable of ...

In addition, our analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of ...