Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Copine-6 is a calcium-sensitive phospholipid-binding protein of the evolutionarily conserved Copine family. In the central nervous system, Copine-6 regulates function of some neurotransmitter ...

Although the Arabidopsis thaliana RPD3-type histone deacetylase HDA19 and its close homolog HDA6 participate in SIN3-type histone deacetylase complexes, they display distinct biological roles, with ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

Stabilization of microtubule plus end-directed kinesin CENP-E at the metaphase kinetochores is important for chromosome alignment, but its mechanism remains unclear. Here, we show that CKAP5, a ...

Notably, one specific branch of the Metaviridae, the Errantiviruses or insect endogenous retroviruses (iERVs), stands out due to a key biological trait: infectivity (Stefanov et al, 2012; Terzian et ...

Arthritis was induced in mice exposed to high blood levels of homocysteine. Hyper-homocysteinemia arthritic animals develop diastolic dysfunction (the left ventricle does not dilate properly) with ...

Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024). Androgen receptor (AR) is ...

LRBA deficiency is a rare genetic immune disorder caused by deleterious biallelic mutations in LRBA (Lopez-Herrera et al, 2012). Clinically, it manifests with a broad spectrum of symptoms ranging from ...

The ER membrane protein SELENOT has been previously suggested to be neuroprotective, but its contribution to neuronal pathophysiology has not been thoroughly investigated. This study reports that ...

Spatial and molecular resolution are important measures to enable spatial metabolomics for microbial systems. Spatial resolution describes the smallest area on a sample that can be individually ...

RAGE belongs to the immunoglobulin superfamily of cell surface receptor. It functions as a pattern recognition receptor that engages a broad repertoire of ligands, including advance glycation end ...