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The meaning of LOCO is in the register as written —used as a direction in music.

Loco (Apache) (1823–1905), Apache chief Loco (nickname), a list of people known as "Loco" or "El Loco" Joe Loco (1921–1988), American jazz and pop pianist and arranger Loco (rapper) (born 1989), …

(Definition of loco from the Cambridge Advanced Learner's Dictionary & Thesaurus © Cambridge University Press)

LOCO definition: locoweed. See examples of loco used in a sentence.

loco in British English (ˈləʊkəʊ ) adjective denoting a price for goods, esp goods to be exported, that are in a place specified or known, the buyer being responsible for all transport charges from that place

Loco is about real people, real action, and in real time. Log on and link up with the streamers you love - and interact with them through live chat, awesome stickers and in many other fun ways.

The crowd went loco when she walked out on the stage. He's not just weird, he's positively loco.

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